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Article

Genetic predisposition for high stress reactivity amplifies effects of early-life adversity.

Psychoneuroendocrinology - 1 Aug 2016

McIlwrick Silja, Rechenberg Alexandra, Matthes Mariana, Burgstaller Jessica, Schwarzbauer Thomas, Chen Alon, Touma Chadi

Abstract excerpt

A dysregulation of the hypothalamus-pituitary-adrenocortical (HPA) axis and the experience of early-life adversity are both well-established risk factors for the development of affective disorders, such as major depression. However, little is known about the interaction of these two factors in shaping endophenotypes of the disease. Here, we studied the gene-environment interaction of a genetic predisposition for...

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Identifiers

PMID: 27179233
DOI: 10.1016/j.psyneuen.2016.04.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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