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Article

CRHR1 genotypes, neural circuits and the diathesis for anxiety and depression.

Molecular psychiatry - 1 Jun 2013

Rogers J, Raveendran M, Fawcett G L, Fox A S, Shelton S E, Oler J A, Cheverud J, Muzny D M, Gibbs R A, Davidson R J, Kalin N H

Abstract excerpt

The corticotrophin-releasing hormone (CRH) system integrates the stress response and is associated with stress-related psychopathology. Previous reports have identified interactions between childhood trauma and sequence variation in the CRH receptor 1 gene (CRHR1) that increase risk for affective disorders. However, the underlying mechanisms that connect variation in CRHR1 to psychopathology are unknown. To...

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Source

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Identifiers

PMID: 23147386
DOI: 10.1038/mp.2012.152
PMCID: PMC3663915

Genes

CRHR1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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