Further serological and RFLP analysis of the MRL-+/+ and MRL-lpr/lpr mice.

doi:10.1111/j.1744-313x.1988.tb00434.x

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Article

Further serological and RFLP analysis of the MRL-+/+ and MRL-lpr/lpr mice.

Journal of immunogenetics - 1 Jan 2000

Delarbre C, Bobe P, Kiger N, Kourilsky P, Gachelin G

Abstract excerpt

During their ageing, MRL-lpr/lpr mice (H-2k) suffer from progressive lymph node enlargement, associated with the development of several acute autoimmune lesions. The primary effect and location of the lpr mutation is unknown. However, a minority of the lymphoid cells of some MRL-+/+, as well as M...

Topics

Animals
Autoimmune Diseases
Epitopes
Genes, MHC Class I
Genes, MHC Class II
Genotype
H-2 Antigens
Major Histocompatibility Complex
Mice
Mice, Mutant Strains
Polymorphism, Restriction Fragment Length

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