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Article

Further serological and RFLP analysis of the MRL-+/+ and MRL-lpr/lpr mice.

Journal of immunogenetics - 1 Jan 2000

Delarbre C, Bobe P, Kiger N, Kourilsky P, Gachelin G

Abstract excerpt

During their ageing, MRL-lpr/lpr mice (H-2k) suffer from progressive lymph node enlargement, associated with the development of several acute autoimmune lesions. The primary effect and location of the lpr mutation is unknown. However, a minority of the lymphoid cells of some MRL-+/+, as well as MRL-lpr/lpr mice, express 'alien' H-2d antigenic specificities. In the course of the investigation of the origin of the...

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Identifiers

PMID: 2475545
DOI: 10.1111/j.1744-313x.1988.tb00434.x

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