Article
Effects of the lpr/lpr mutation on T and B cell populations in the lamina propria of the small intestine, a mucosal effector site.
International immunology - 1 Sept 1992
Aicher W K, Fujihashi K, Yamamoto M, Kiyono H, Pitts A M, McGhee J R
Abstract excerpt
MRL mice, which develop a lymphoproliferative disease characterized by increased numbers of alpha/beta T cell receptor+ (TCR+) B220/6B2+CD4-CD8- T cells [lymphoproliferation (lpr) T cells], were studied for the effect of the lpr/lpr mutation on the mucosal immune system in the gastrointestinal (GI) tract. We analyzed the effect of the lpr gene mutation on T and B cell populations in the Peyer's patches (PP) and...
Topics
- Animals
- Autoimmune Diseases
- B-Lymphocytes
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Immunoglobulin A
- Immunoglobulin G
- Intestinal Mucosa
- Intestine, Small
- Lymphoproliferative Disorders