Article
Genetic dissection of the complex pathological manifestations of collagen disease in MRL/lpr mice.
Pathology international - 1 Nov 1999
Nakatsuru S, Terada M, Nishihara M, Kamogawa J, Miyazaki T, Qu W M, Morimoto K, Yazawa C, Ogasawara H, Abe Y, Fukui K, Ichien G, Ito M R, Mori S, Nakamura Y, Nose M
Abstract excerpt
An MRL strain of mice bearing a Fas-deletion mutant gene, lpr, MRL/MpJ-lpr/lpr (MRL/lpr) develops collagen disease involving vasculitis, glomerulonephritis, arthritis and sialoadenitis, each of which has been studied as a model for polyarteritis, lupus nephritis, rheumatoid arthritis and Sjögren's syndrome, respectively. Development of such lesions seems dependent on host genetic background since the congenic...
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