Article
Aberrant expression and dysfunction of Fas antigen in MRL/MpJ-lpr/lpr murine ovary.
Zygote (Cambridge, England) - 1 Nov 1998
Xu J P, Li X, Mori E, Guo M W, Mori T
Abstract excerpt
In lpr mice the insertion of an early transposable element (ETn) into intron 2 of the Fas gene, which mediates apoptosis, causes the development of massive lymphadenopathy, splenomegaly and autoimmune disease. In the present study we investigated the influence of this mutation on ovarian developm...
Topics
- Animals
- Antibodies, Monoclonal
- Apoptosis
- Cell Line
- Fas Ligand Protein
- Female
- Gene Expression
- In Situ Hybridization
- Lymphoproliferative Disorders
- Membrane Glycoproteins
- Mice
- Mice, Inbred MRL lpr
- Mutation
- Ovary
- RNA, Messenger
- Spodoptera
- fas Receptor