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Article

Aberrant expression and dysfunction of Fas antigen in MRL/MpJ-lpr/lpr murine ovary.

Zygote (Cambridge, England) - 1 Nov 1998

Xu J P, Li X, Mori E, Guo M W, Mori T

Abstract excerpt

In lpr mice the insertion of an early transposable element (ETn) into intron 2 of the Fas gene, which mediates apoptosis, causes the development of massive lymphadenopathy, splenomegaly and autoimmune disease. In the present study we investigated the influence of this mutation on ovarian development of lpr mice. By means of in situ hybridisation, the expression of Fas mRNA was detected at the same levels in the...

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Identifiers

PMID: 9921647
DOI: 10.1017/s096719949800032x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aberrant expression and dysfunction of Fas antigen in MRL/MpJ-lpr/lpr murine ovary.PMID 9921647Read ↗

MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease.Semantic proximity Read ↗

The APO-1/Fas (CD95) receptor is expressed in homozygous MRL/lpr mice.Semantic proximity Read ↗

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.Semantic proximity Read ↗

Lethal effect of the anti-Fas antibody in mice.Semantic proximity Read ↗

Mutations in the Fas antigen gene in lpr mice.Semantic proximity Read ↗

Spontaneous autoimmune skin lesions of MRL/n mice: autoimmune disease-prone genetic background in relation to Fas-defect MRL/1pr mice.Semantic proximity Read ↗

Functional analyses of lpr gene in MRL/Mp-lpr/lpr mice. Role of lymph node stromal cells in lpr-lymphadenopathy.Semantic proximity Read ↗

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.Semantic proximity Read ↗

Immunological and pathological consequences of mutations in both Fas and Fas ligand.Semantic proximity Read ↗

Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice.Semantic proximity Read ↗

Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production.Semantic proximity Read ↗

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.Semantic proximity Read ↗

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