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Article

Variations in mismatch repair genes and colorectal cancer risk and clinical outcome.

Mutagenesis - 1 Jul 2014

Vymetalkova Veronika, Pardini Barbara, Rosa Fabio, Di Gaetano Cornelia, Novotny Jan, Levy Miroslav, Buchler Tomas, Slyskova Jana, Vodickova Ludmila, Naccarati Alessio, Vodicka Pavel

Abstract excerpt

DNA mismatch repair (MMR) deficiency is one of the best understood forms of genetic instability in colorectal cancer (CRC). CRC is routinely cured by 5-fluorouracil (5-FU)-based chemotherapy, with a prognostic effect and resistance to such therapy conferred by MMR status. In this study, we aimed to analyse the effect of genetic variants in classical coding regions or in less-explored predicted microRNA...

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Source

Identifiers

PMID: 24755277
DOI: 10.1093/mutage/geu014

Genes

MLH3
MSH6

Variants

rs1800935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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