Article
Common variants in mismatch repair genes and risk of colorectal cancer.
Gut - 1 Aug 2008
Koessler T, Oestergaard M Z, Song H, Tyrer J, Perkins B, Dunning A M, Easton D F, Pharoah P D P
Abstract excerpt
BACKGROUND AND AIMS: The mismatch repair (MMR) genes are in charge of maintaining genomic integrity. Mutations in the MMR genes are at the origin of a familial form of colorectal cancer (CRC). This syndrome accounts for only a small proportion of the excess familial risk of CRC. The characteristics of the alleles that account for the remainder of cases are unknown. To assess the putative associations between...
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