Article
The polymorphisms of miRNA-binding site in MLH3 and ERCC1 were linked to the risk of colorectal cancer in a case-control study.
Cancer medicine - 1 Apr 2018
Zhang Qianye, Zheng Xiao, Li Xiaoxia, Sun Deyu, Xue Ping, Zhang Guopei, Xiao Mingyang, Cai Yuan, Jin Cuihong, Yang Jinghua, Wu Shengwen, Lu Xiaobo
Abstract excerpt
Colorectal cancer (CRC), as a malignant tumor of lower digestive tract, has been found to have an increasing morbidity and mortality in China. It was particularly important to find some earlier biomarkers to predict the risk and prognosis. In this study, several polymorphisms on 3'UTR of three DNA repair genes including MLH3 rs10862, ERCC1 rs3212986, ERCC1 rs735482, ERCC1 rs2336219, and OGG1 rs1052133 were chosen...