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Article

Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors.

Gut - 1 May 2009

Campbell P T, Curtin K, Ulrich C M, Samowitz W S, Bigler J, Velicer C M, Caan B, Potter J D, Slattery M L

Abstract excerpt

BACKGROUND: Germline mutations in DNA mismatch repair (MMR) genes cause Lynch syndrome colon cancers. Less understood is the risk of colon cancer associated with common polymorphisms in MMR genes and the potential interacting role of lifestyle factors known to damage DNA. METHODS: A study was conducted to examine whether MLH1 (-93G>A and Ile219Val) and MSH6 (Gly39Glu) polymorphisms were associated with risk of...

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Share to Colonic Neoplasms
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Germ-Line Mutation

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Share to MutL Protein Homolog 1

Source

Open in PubMed Open full text

Identifiers

PMID: 18523027
DOI: 10.1136/gut.2007.144220
PMCID: PMC2903215

Genes

MLH1
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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