DNA Mismatch Repair Deficiency in Rectal Cancer: Benchmarking Its Impact on Prognosis, Neoadjuvant Response Prediction, and Clinical Cancer Genetics.

doi:10.1200/JCO.2016.66.6826

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Article

DNA Mismatch Repair Deficiency in Rectal Cancer: Benchmarking Its Impact on Prognosis, Neoadjuvant Response Prediction, and Clinical Cancer Genetics.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2016

de Rosa Nicole, Rodriguez-Bigas Miguel A, Chang George J, Veerapong Jula, Borras Ester, Krishnan Sunil, Bednarski Brian, Messick Craig A, Skibber John M, Feig Barry W, Lynch Patrick M, Vilar Eduardo, You Y Nancy

Abstract excerpt

PURPOSE: DNA mismatch repair deficiency (dMMR) hallmarks consensus molecular subtype 1 of colorectal cancer. It is being routinely tested, but little is known about dMMR rectal cancers. The efficacy of novel treatment strategies cannot be established without benchmarking the outcomes of dMMR rectal cancer with current therapy. We aimed to delineate the impact of dMMR on prognosis, the predicted response to...

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PMID: 27432916
DOI: 10.1200/JCO.2016.66.6826
PMCID: PMC5012714

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