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Article

Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association.

Nucleic acids research - 1 Jun 2014

Sarangi Prabha, Bartosova Zdenka, Altmannova Veronika, Holland Cory, Chavdarova Melita, Lee Sang Eun, Krejci Lumir, Zhao Xiaolan

Abstract excerpt

The Saccharomyces cerevisiae Rad1-Rad10 complex is a conserved, structure-specific endonuclease important for repairing multiple types of DNA lesions. Upon recruitment to lesion sites, Rad1-Rad10 removes damaged sequences, enabling subsequent gap filling and ligation. Acting at mid-steps of repair, the association and dissociation of Rad1-Rad10 with DNA can influence repair efficiency. We show that...

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Identifiers

PMID: 24753409
DOI: 10.1093/nar/gku300
PMCID: PMC4041466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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