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Article

SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress.

Journal of molecular cell biology - 1 Oct 2018

Xu Xiaoli, Shi Rongyi, Zheng Li, Guo Zhigang, Wang Liangyan, Zhou Mian, Zhao Ye, Tian Bing, Truong Khue, Chen Yuan, Shen Binghui, Hua Yuejin, Xu Hong

Abstract excerpt

Human flap endonuclease 1 (FEN1) is a structure-specific, multi-functional endonuclease essential for DNA replication and repair. We and others have shown that during DNA replication, FEN1 processes Okazaki fragments via its interaction with the proliferating cell nuclear antigen (PCNA). Alternatively, in response to DNA damage, FEN1 interacts with the PCNA-like Rad9-Rad1-Hus1 complex instead of PCNA to engage in...

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Identifiers

PMID: 30184152
DOI: 10.1093/jmcb/mjy047
PMCID: PMC6231531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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