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Article

Lif1 SUMOylation and its role in non-homologous end-joining.

Nucleic acids research - 1 May 2013

Vigasova Dana, Sarangi Prabha, Kolesar Peter, Vlasáková Danusa, Slezakova Zuzana, Altmannova Veronika, Nikulenkov Fedor, Anrather Dorothea, Gith Rainer, Zhao Xiaolan, Chovanec Miroslav, Krejci Lumir

Abstract excerpt

Non-homologous end-joining (NHEJ) repairs DNA double-strand breaks by tethering and ligating the two DNA ends. The mechanisms regulating NHEJ efficiency and interplay between its components are not fully understood. Here, we identify and characterize the SUMOylation of budding yeast Lif1 protein, which is required for the ligation step in NHEJ. We show that Lif1 SUMOylation occurs throughout the cell cycle and...

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Identifiers

PMID: 23571759
DOI: 10.1093/nar/gkt236
PMCID: PMC3664818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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