Article
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.
Genome research - 1 Mar 2006
Moran Jennifer L, Bolton Andrew D, Tran Pamela V, Brown Alison, Dwyer Noelle D, Manning Danielle K, Bjork Bryan C, Li Cheng, Montgomery Kate, Siepka Sandra M, Vitaterna Martha Hotz, Takahashi Joseph S, Wiltshire Tim, Kwiatkowski David J, Kucherlapati Raju, Beier David R
Abstract excerpt
Phenotype-driven genetics can be used to create mouse models of human disease and birth defects. However, the utility of these mutant models is limited without identification of the causal gene. To facilitate genetic mapping, we developed a fixed single nucleotide polymorphism (SNP) panel of 394 SNPs as an alternative to analyses using simple sequence length polymorphism (SSLP) marker mapping. With the SNP panel,...
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