Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis.

Genetics - 1 Mar 2011

Arnold Carrie N, Xia Yu, Lin Pei, Ross Charles, Schwander Martin, Smart Nora G, Müller Ulrich, Beutler Bruce

Abstract excerpt

In a pedigree of C57BL/6J mice homozygous for germline mutations induced by the mutagen N-ethyl-N-nitrosourea (ENU), numerous animals died under specific pathogen-free (SPF) conditions between 6 and 7 months of age. Death was caused by nephritic syndrome, which progressed to renal failure associated with focal segmental glomerulosclerosis. To identify the mutation responsible for renal disease, we sequenced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Segregation
Share to Collagen Type IV

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethylnitrosourea

Share to Germ-Line Mutation

Share to Glomerulosclerosis, Focal Segmental

Share to Proteinuria

Share to Renal Insufficiency

Share to RNA Splice Sites

Source

Open in PubMed Open full text

Identifiers

PMID: 21196518
DOI: 10.1534/genetics.110.124586
PMCID: PMC3063661

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis.PMID 21196518Read ↗

Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome.Semantic proximity Read ↗

Real-time resolution of point mutations that cause phenovariance in mice.Semantic proximity Read ↗

Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.Semantic proximity Read ↗

Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models.Semantic proximity Read ↗

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing.Semantic proximity Read ↗

Bulk segregation mapping of mutations in closely related strains of mice.Semantic proximity Read ↗

Genome-wide analysis of chemically induced mutations in mouse in phenotype-driven screens.Semantic proximity Read ↗

Analysis pipelines for cancer genome sequencing in mice.Semantic proximity Read ↗

Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.Semantic proximity Read ↗

Random mutagenesis of the mouse genome: a strategy for discovering gene function and the molecular basis of disease.Semantic proximity Read ↗

Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.Semantic proximity Read ↗

Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.