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Article

Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc (Min/+) mutation.

BMC genetics - 19 Feb 2016

Dorman Alexandra, Baer Daria, Tomlinson Ian, Mott Richard, Iraqi Fuad A

Abstract excerpt

BACKGROUND: Colorectal cancer is an abnormal tissue development in the colon or rectum. Most of CRCs develop due to somatic mutations, while only a small proportion is caused by inherited mutations. Familial adenomatous polyposis is an inherited genetic disease, which is characterized by colorectal polyps. It is caused by inactivating mutations in the Adenomatous polyposis coli gene. Mice carrying and non-sense...

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Identifiers

PMID: 26896154
DOI: 10.1186/s12863-016-0349-6
PMCID: PMC4761170

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic analysis of intestinal polyp development in Collaborative Cross mice carrying the Apc (Min/+) mutation.PMID 26896154Read ↗

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Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

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Studying the Effect of Host Genetic Background of Juvenile Polyposis Development using Collaborative Cross and Smad4 Knock-out Mouse ModelsSemantic proximity Read ↗

The CAST/Ei strain confers significant protection against Apc(Min) intestinal polyps, independent of the resistant modifier of Min 1 (Mom1) locus.Semantic proximity Read ↗

Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to ApcMin intestinal tumorigenesis.Semantic proximity Read ↗

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PWD/Ph-Encoded Genetic Variants Modulate the Cellular Wnt/β-Catenin Response to Suppress Apc Min-Triggered Intestinal Tumor Formation.Semantic proximity Read ↗

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