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Bulk segregation mapping of mutations in closely related strains of mice.

Genetics - 1 Dec 2010

Xia Yu, Won Sungyong, Du Xin, Lin Pei, Ross Charles, La Vine Diantha, Wiltshire Sean, Leiva Gabriel, Vidal Silvia M, Whittle Belinda, Goodnow Christopher C, Koziol James, Moresco Eva Marie Y, Beutler Bruce

Abstract excerpt

Phenovariance may be obscured when genetic mapping is performed using highly divergent strains, and closely similar strains are preferred if adequate marker density can be established. We sequenced the C57BL/10J mouse genome using the Applied Biosystems SOLiD platform and here describe a genome-wide panel of informative markers that permits the mapping of mutations induced on the closely related C57BL/6J...

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PMID: 20923982
DOI: 10.1534/genetics.110.121160
PMCID: PMC2998299

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Source receipt: pubmed, retrieved 7 Sept 2026.

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