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Uracil in DNA and its processing by different DNA glycosylases

13 Nov 2008

Abstract excerpt

Uracil in DNA may result from incorporation of dUMP during replication and from spontaneous or enzymatic deamination of cytosine, resulting in U:A pairs or U:G mismatches, respectively. Uracil generated by activation-induced cytosine deaminase (AID) in B cells is a normal intermediate in adaptive immunity. Five mammalian uracil-DNA glycosylases have been identified; these are mitochondrial UNG1 and nuclear UNG2,...

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Identifiers

PMID: 19008197
DOI: 10.1098/rstb.2008.0186

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