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Article

A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.

Biochimica et biophysica acta - 1 May 2009

Fung King Leung, Gottesman Michael M

Abstract excerpt

The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant cancer cells is a serious impediment to chemotherapy. MDR1 is expressed in various tissues to protect them from the adverse effect of toxins. The pharmacokinetics of drugs that are also MDR1 substrates also influence disease outcome and treatment...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Source

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Identifiers

PMID: 19285158
DOI: 10.1016/j.bbapap.2009.02.014
PMCID: PMC2810319

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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