Article
Association of genetic polymorphism in ABCC2 with hepatic multidrug resistance-associated protein 2 expression and pravastatin pharmacokinetics.
Pharmacogenetics and genomics - 1 Nov 2006
Niemi Mikko, Arnold Katja A, Backman Janne T, Pasanen Marja K, Gödtel-Armbrust Ute, Wojnowski Leszek, Zanger Ulrich M, Neuvonen Pertti J, Eichelbaum Michel, Kivistö Kari T, Lang Thomas
Abstract excerpt
OBJECTIVE: Our aim was to investigate possible effects of sequence variations in ABCC2, encoding the multidrug resistance-associated protein 2 (MRP2), on the pharmacokinetics of the MRP2 substrate pravastatin. METHODS: Deoxyribonucleic acid samples of 41 healthy volunteers, in whom SLCO1B1 single nucleotide polymorphisms (SNPs) and haplotypes had previously been found to be associated with increased plasma...
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