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Article

Impact of ABCC2 haplotypes on transcriptional and posttranscriptional gene regulation and function.

The pharmacogenomics journal - 1 Feb 2011

Laechelt S, Turrini E, Ruehmkorf A, Siegmund W, Cascorbi I, Haenisch S

Abstract excerpt

ABCC2 (MRP2) is an important export pump, expressed at tissue barriers. The genetic variants -24C>T, 1249G>A and 3972C>T are leading to inter-individual differences of bioavailability of various endogenous and exogenous compounds. Considering ABCC2 haplotypes, we investigated DNA-protein binding properties, mRNA secondary structure, mRNA stability, protein expression and transport activity in various cell lines...

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Source

Identifiers

PMID: 20351751
DOI: 10.1038/tpj.2010.20

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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