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Article

Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2).

Pharmacogenetics and genomics - 1 Aug 2011

Megaraj Vandana, Zhao Tianyong, Paumi Christian M, Gerk Phillip M, Kim Richard B, Vore Mary

Abstract excerpt

BACKGROUND: Multidrug resistance-associated protein 2 (MRP2; ABCC2) mediates the biliary excretion of glutathione, glucuronide, and sulfate conjugates of endobiotics and xenobiotics. Single nucleotide polymorphisms (SNPs) of MRP2 contribute to interindividual variability in drug disposition and ultimately in drug response. OBJECTIVES: To characterize the transport function of human wild-type (WT) MRP2 and four...

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Source

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Identifiers

PMID: 21691255
DOI: 10.1097/FPC.0b013e328348c786
PMCID: PMC3640355

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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