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A SNP (rs34678167, 805 C>T, P269S) in the Human ABC Transporter ABCG2 Gene increases ABCG2-mediated Drug Resistance

2025-06-11

Abstract excerpt

<title>Abstract</title> <p> ABCG2 (BCRP/MXR) is an ATP-binding cassette transporter that contributes to multidrug resistance in cancer cells by extruding a wide range of substrates, including anticancer agents. Although several non-synonymous single-nucleotide polymorphisms (SNPs) in the <italic>ABCG2</italic> gene have been characterized, the functional consequences of many remain unclear. This study investig...

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Literature Corpus work
19d3a12a-70d5-51b2-8147-4c1b76db716f
DOI
10.21203/rs.3.rs-6704269/v1
Open publication

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A SNP (rs34678167, 805 C&gt;T, P269S) in the Human ABC Transporter ABCG2 Gene increases ABCG2-mediated Drug ResistanceDOI 10.21203/rs.3.rs-6704269/v1
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