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Article

CHRNB3 c.-57A>G functional promoter change affects Parkinson's disease and smoking.

Neurobiology of aging - 1 Sept 2014

Bar-Shira Anat, Gana-Weisz Mali, Gan-Or Ziv, Giladi Eytan, Giladi Nir, Orr-Urtreger Avi

Abstract excerpt

Cigarette smoking is protective in Parkinson's disease (PD), possibly because of nicotine action on brain nicotinic-acetylcholine receptors. The β3 nicotinic-acetylcholine receptor subunit (encoded by CHRNB3) is depleted in the striatum of PD patients and associated with nicotine dependence. Here...

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Source

Identifiers

PMID: 24731518
DOI: 10.1016/j.neurobiolaging.2014.03.014

Genes

CHRNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24731518-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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