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Article

Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction.

Parkinsonism & related disorders - 1 Jan 2013

Greenbaum Lior, Rigbi Amihai, Lipshtat Nurit, Cilia Roberto, Tesei Silvana, Asselta Rosanna, Djaldetti Ruth, Goldwurm Stefano, Lerer Bernard

Abstract excerpt

BACKGROUND: Smoking is a well documented environmental factor that reduces susceptibility to Parkinson's disease (PD). Several genetic variants within the nicotinic cholinergic receptor gene cluster, CHRNA5-CHRNA3-CHRNB4 have been reported to be associated with nicotine dependence (ND), and this association has been validated in multiple studies. OBJECTIVES: Due to the inverse correlation between smoking and PD...

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Source

Identifiers

PMID: 22884254
DOI: 10.1016/j.parkreldis.2012.07.007

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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