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Article

An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease.

Neuro-degenerative diseases - 1 Jan 2011

Gao Jianjun, Xu Hong, Weinberg Clarice, Huang Xuemei, Park Yikyung, Hollenbeck Albert, Blair Aaron, Schatzkin Arthur, Burch Lauranell, Chen Honglei

Abstract excerpt

BACKGROUND: Smokers have a lower risk of Parkinson's disease (PD). Recent genome-wide association studies (GWAS) have consistently linked several single nucleotide polymorphisms (SNPs) in the CHRNA3-CHRNA5-CHRNB4 cluster on chromosome 15.q25 to smoking behaviors and nicotine dependence. Investigations into these SNPs may help explain the nature and mechanisms of the smoking-PD relationship. OBJECTIVE: To examine...

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Source

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Identifiers

PMID: 21228559
DOI: 10.1159/000323190
PMCID: PMC3121544

Genes

CHRNA3
CHRNA5
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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