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Article

Identification of rs2036527 as a cis-regulatory variant for CHRNA3 and CHRNA5 by allele-specific expression and implications for nicotine dependence and lung cancer.

The American journal on addictions - 1 May 2026

Peng Tao, Shi Xiao-Qian, Guo Hao, Li Hai-Yan, Zhou Xi-Ting, Song Hong-Li, Zhang Xin-Xin, Fu Wei-Ping, Sun Chang

Abstract excerpt

BACKGROUND AND OBJECTIVES: Numerous genome-wide association studies suggest that rs1051730 is significantly associated with nicotine dependence and further lung cancer in Caucasian. Since rs1051730 is a synonymous variant at CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit), it might be hypothesized that the causal variant might be other SNP(s) in strong linkage disequilibrium (LD). METHODS: LD analysis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40755048
DOI: 10.1111/ajad.70074

Genes

CHRNA3
CHRNA5
FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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