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Article

Genotyping accuracy of high-resolution DNA melting instruments.

Clinical chemistry - 1 Jun 2014

Li Mei, Zhou Luming, Palais Robert A, Wittwer Carl T

Abstract excerpt

BACKGROUND: High-resolution DNA melting is a closed-tube method for genotyping and variant scanning that depends on the thermal stability of PCR-generated products. Instruments vary in thermal precision, sample format, melting rates, acquisition, and software. Instrument genotyping accuracy has not been assessed. METHODS: Each genotype of the single nucleotide variant (SNV) (c.3405-29A>T) of CPS1...

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Source

Identifiers

PMID: 24718912
DOI: 10.1373/clinchem.2013.220160

Genes

CPS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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