Article
Is high resolution melting analysis (HRMA) accurate for detection of human disease-associated mutations? A meta analysis.
PloS one - 1 Jan 2011
Li Bing-Sheng, Wang Xin-Ying, Ma Feng-Li, Jiang Bo, Song Xiao-Xiao, Xu An-Gao
Abstract excerpt
BACKGROUND: High Resolution Melting Analysis (HRMA) is becoming the preferred method for mutation detection. However, its accuracy in the individual clinical diagnostic setting is variable. To assess the diagnostic accuracy of HRMA for human mutations in comparison to DNA sequencing in different routine clinical settings, we have conducted a meta-analysis of published reports. METHODOLOGY/PRINCIPAL FINDINGS: Out...
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