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Article

Base-pair neutral homozygotes can be discriminated by calibrated high-resolution melting of small amplicons.

Nucleic acids research - 1 Jun 2008

Gundry Cameron N, Dobrowolski Steven F, Martin Y Ranae, Robbins Thomas C, Nay Lyle M, Boyd Nathan, Coyne Thomas, Wall Mikeal D, Wittwer Carl T, Teng David H-F

Abstract excerpt

Genotyping by high-resolution melting analysis of small amplicons is homogeneous and simple. However, this approach can be limited by physical and chemical components of the system that contribute to intersample melting variation. It is challenging for this method to distinguish homozygous G::C f...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18448472
DOI: 10.1093/nar/gkn204
PMCID: PMC2425497

Genes

CPS1
MSH2
OTC
PAH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18448472-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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