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Article

Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse.

Molecular endocrinology (Baltimore, Md.) - 1 Jun 2014

Hewitt Sylvia C, Li Leping, Grimm Sara A, Winuthayanon Wipawee, Hamilton Katherine J, Pockette Brianna, Rubel Cory A, Pedersen Lars C, Fargo David, Lanz Rainer B, DeMayo Francesco J, Schütz Günther, Korach Kenneth S

Abstract excerpt

Estrogen receptor α (ERα) interacts with DNA directly or indirectly via other transcription factors, referred to as "tethering." Evidence for tethering is based on in vitro studies and a widely used "KIKO" mouse model containing mutations that prevent direct estrogen response element DNA- binding. KIKO mice are infertile, due in part to the inability of estradiol (E2) to induce uterine epithelial proliferation....

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Identifiers

PMID: 24713037
DOI: 10.1210/me.2014-1051
PMCID: PMC4042070

Genes

KLF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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