Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome‐wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activity

23 Mar 2021

Abstract excerpt

Colorectal cancer (CRC) is the third leading cause of cancer death in the western world. In women, menopausal hormone therapy has been shown to reduce CRC incidence by 20%. Studies demonstrate that estrogen activating estrogen receptor beta (ERβ) protects against CRC. ERβ is a nuclear receptor that regulates gene expression through interactions with the chromatin. This molecular mechanism is, however, not well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Estrogen and related hormone effects
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33754337
DOI: 10.1002/ijc.33573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome‐wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activityPMID 33754337Read ↗

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancerSemantic proximity Read ↗

Genome-wide DNA methylation differences according to oestrogen receptor beta status in colorectal cancerSemantic proximity Read ↗

Estrogen Receptors in Colorectal Cancer: Facts, Novelties and PerspectivesSemantic proximity Read ↗

Upregulation of <i>GREB1</i> in colorectal cancer ovarian metastases may be a potential therapeutic targetSemantic proximity Read ↗

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory FactorSemantic proximity Read ↗

GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancerSemantic proximity Read ↗

Sex Steroid Receptors in Colorectal Cancer: Implications for Tumor Progression, Therapeutic Opportunities, and Sex-Specific OutcomesSemantic proximity Read ↗

Estrogen-related receptor alpha (ERRα) promotes gastrointestinal stromal tumor progression and epithelial-mesenchymal transition through Wnt/β-cateninSemantic proximity Read ↗

FGF2 induces breast cancer growth through ligand‐independent activation and recruitment of ERα and PRBΔ4 isoform to MYC regulatory sequencesSemantic proximity Read ↗

EstroGene database reveals diverse temporal, context-dependent and directional estrogen receptor regulomes in breast cancerSemantic proximity Read ↗

Interaction Proteomics Identifies ERbeta Association with Chromatin Repressive Complexes to Inhibit Cholesterol Biosynthesis and Exert An Oncosuppressive Role in Triple-negative Breast CancerSemantic proximity Read ↗

Genomic Function of Estrogen Receptor β in EndometriosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.