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Article

Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements.

The Journal of biological chemistry - 8 Sept 2006

O'Brien Jeanne E, Peterson Theresa J, Tong Ming Han, Lee Eun-Jig, Pfaff Liza E, Hewitt Sylvia C, Korach Kenneth S, Weiss Jeffrey, Jameson J Larry

Abstract excerpt

Acting via the estrogen receptor (ER), estradiol exerts pleomorphic effects on the uterus, producing cyclical waves of cellular proliferation and differentiation in preparation for embryo implantation. In the classical pathway, the ER binds directly to an estrogen response element to activate or repress gene expression. However, emerging evidence supports the existence of nonclassical pathways in which the...

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Identifiers

PMID: 16847062
DOI: 10.1074/jbc.M601522200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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