Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms.

The Journal of biological chemistry - 8 Apr 2011

Burns Katherine A, Li Yin, Arao Yukitomo, Petrovich Robert M, Korach Kenneth S

Abstract excerpt

The three main mechanisms of ERα action are: 1) nuclear, genomic, direct DNA binding, 2) nuclear, genomic, "tethered"-mediated, protein-protein interactions, and 3) non-nuclear, non-genomic, rapid action responses. Reports suggest the D-domain or hinge region of ERα plays an important role in mec...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Estrogen Receptor alpha
Share to HeLa Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoprecipitation

Share to Microscopy, Confocal

Share to Protein Transport

Share to Proto-Oncogene Proteins c-jun

Share to Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 21285458
DOI: 10.1074/jbc.M110.187773
PMCID: PMC3069464

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21285458-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms.PMID 21285458Read ↗

Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies.Semantic proximity Read ↗

Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and secondary effectsSemantic proximity Read ↗

Estrogen Receptor Alpha Mutations in Breast Cancer Cells Cause Gene Expression Changes through Constant Activity and Secondary Effects.Semantic proximity Read ↗

Identification of Regions within the F Domain of the Human Estrogen Receptor α that Are Important for Modulating Transactivation and Protein-Protein InteractionsSemantic proximity Read ↗

Human C-terminally truncated ERα variants resulting from the use of alternative exons in the ligand-binding domain.Semantic proximity Read ↗

Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation.Semantic proximity Read ↗

Clinically Observed Estrogen Receptor Alpha Mutations within the Ligand-Binding Domain Confer Distinguishable Phenotypes.Semantic proximity Read ↗

Allele-Specific Gene Regulation, Phenotypes, and Therapeutic Vulnerabilities in Estrogen Receptor Alpha-Mutant Endometrial Cancer.Semantic proximity Read ↗

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations.Semantic proximity Read ↗

Estrogen receptor (ER)-β isoforms: A key to understanding ER-β signalingSemantic proximity Read ↗

Estrogen receptors (ER<sub>α</sub>versus ER<sub>β</sub>): friends or foes in human biology?Semantic proximity Read ↗

Estrogen receptor mutations and functional consequences for breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.