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Article

Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.

The Journal of biological chemistry - 23 May 2014

Lee Miju, Lee Chul-Hwan, Demin Annie Albert, Munashingha Palinda Ruvan, Amangyeld Tamir, Kwon Buki, Formosa Tim, Seo Yeon-Soo

Abstract excerpt

The correct removal of 5'-flap structures by Rad27 and Dna2 during Okazaki fragment maturation is crucial for the stable maintenance of genetic materials and cell viability. In this study, we identified RAD52, a key recombination protein, as a multicopy suppressor of dna2-K1080E, a lethal helicase-negative mutant allele of DNA2 in yeasts. In contrast, the overexpression of Rad51, which works conjointly with Rad52...

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Share to DNA Helicases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24711454
DOI: 10.1074/jbc.M114.548388
PMCID: PMC4031557

Genes

DNA2
RAD52

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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