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Article

The endonuclease activity of the yeast Dna2 enzyme is essential in vivo.

Nucleic acids research - 1 Aug 2000

Lee K H, Kim D W, Bae S H, Kim J A, Ryu G H, Kwon Y N, Kim K A, Koo H S, Seo Y S

Abstract excerpt

Dna2 is a multifunctional enzyme in yeast that possesses endonuclease activity well suited to remove RNA-DNA primers of Okazaki fragments, raising the question of whether endonuclease activity is essential for in vivo Dna2 function. Systematic site-directed mutations of amino acid residues in Saccharomyces cerevisiae DNA2 conserved in the central region of many eukaryotic DNA2 homologs allowed us to identify...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10908349
DOI: 10.1093/nar/28.15.2873
PMCID: PMC102684

Genes

DNA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The endonuclease activity of the yeast Dna2 enzyme is essential in vivo.PMID 10908349Read ↗

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