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Article

Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jul 2001

Debrauwère H, Loeillet S, Lin W, Lopes J, Nicolas A

Abstract excerpt

The RAD27 gene of Saccharomyces cerevisiae encodes a 5'-3' flap exo/endonuclease, which plays an important role during DNA replication for Okazaki fragment maturation. Genetic studies have shown that RAD27 is not essential for growth, although rad27 Delta mutants are temperature sensitive. Moreover, they exhibit increased sensitivity to alkylating agents, enhanced spontaneous recombination, and repetitive DNA...

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Identifiers

PMID: 11459962
DOI: 10.1073/pnas.121075598
PMCID: PMC37430

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Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity.PMID 11459962Read ↗

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