Article
Quinacrine promotes replication and conformational mutation of chronic wasting disease prions.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2014
Bian Jifeng, Kang Hae-Eun, Telling Glenn C
Abstract excerpt
Quinacrine's ability to reduce levels of pathogenic prion protein (PrP(Sc)) in mouse cells infected with experimentally adapted prions led to several unsuccessful clinical studies in patients with prion diseases, a 10-y investment to understand its mechanism of action, and the production of related compounds with expectations of greater efficacy. We show here, in stark contrast to this reported inhibitory effect,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.