Article
Prion propagation is controlled by discrete structural regions of PrP rather than overall stability.
The Journal of biological chemistry - 1 Jul 2026
Bhamra Savroop K, Arora Parineeta, Liew May, Hosszu Laszlo L P, Batchelor Mark, Clarke Anthony R, Bieschke Jan, Collinge John, Jat Parmjit S
Abstract excerpt
Mutational analysis of the cellular prion protein (PrPC) has revealed various regions of the protein that modulate prion propagation. However, these approaches involve deletions, insertions, or replacements in the presence of the WT PrPC, which may mask the true phenotype. Here, site-directed alanine mutagenesis of the prion protein (PrP) was conducted to identify sites, particularly potential "surface patches"...
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