Article
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes.
Proceedings of the National Academy of Sciences of the United States of America - 12 Dec 2006
Legname Giuseppe, Nguyen Hoang-Oanh B, Peretz David, Cohen Fred E, DeArmond Stephen J, Prusiner Stanley B
Abstract excerpt
On passaging synthetic prions, two isolates emerged with incubation times differing by nearly 100 days. Using conformational-stability assays, we determined the guanidine hydrochloride (Gdn.HCl) concentration required to denature 50% of disease-causing prion protein (PrP(Sc)) molecules, denoted as the [Gdn.HCl](1/2) value. For the two prion isolates enciphering shorter and longer incubation times, [Gdn.HCl](1/2)...
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