Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emergence and natural selection of drug-resistant prions

27 Apr 2010

Abstract excerpt

Drug resistance is a refractory barrier in the battle against many fatal diseases caused by rapidly evolving agents, including HIV, apicomplexans and specific cancers. Emerging evidence suggests that drug resistance might extend to lethal prion disorders and related neurodegenerative amyloidoses. Prions are self-replicating protein conformers, usually 'cross-beta' amyloid polymers, which are naturally transmitted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neurological diseases and metabolism
Share to Prion Diseases and Protein Misfolding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20422111
DOI: 10.1039/c004550k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emergence and natural selection of drug-resistant prionsPMID 20422111Read ↗

Prions on the move.Semantic proximity Read ↗

Medicine. Prion strain mutation and selection.Semantic proximity Read ↗

A dominant-negative mutant inhibits multiple prion variants through a common mechanism.Semantic proximity Read ↗

Quinacrine promotes replication and conformational mutation of chronic wasting disease prions.Semantic proximity Read ↗

Approaches for discovering anti-prion compounds: lessons learned and challenges ahead.Semantic proximity Read ↗

Mutation and selection of prions.Semantic proximity Read ↗

Therapeutic strategies for identifying small molecules against prion diseasesSemantic proximity Read ↗

Evidence for preexisting prion substrain diversity in a biologically cloned prion strain.Semantic proximity Read ↗

Prion recognition elements govern nucleation, strain specificity and species barriers.Semantic proximity Read ↗

Unraveling prion strains with cell biology and organic chemistry.Semantic proximity Read ↗

Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivoSemantic proximity Read ↗

Prion; the unconventional slow infectious agent.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.