Article
An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.
PloS one - 1 Jan 2017
Stincardini Claudia, Massignan Tania, Biggi Silvia, Elezgarai Saioa R, Sangiovanni Valeria, Vanni Ilaria, Pancher Michael, Adami Valentina, Moreno Jorge, Stravalaci Matteo, Maietta Giulia, Gobbi Marco, Negro Alessandro, Requena Jesús R, Castilla Joaquín, Nonno Romolo, Biasini Emiliano
Abstract excerpt
Prion diseases are neurodegenerative conditions characterized by the conformational conversion of the cellular prion protein (PrPC), an endogenous membrane glycoprotein of uncertain function, into PrPSc, a pathological isoform that replicates by imposing its abnormal folding onto PrPC molecules. A great deal of evidence supports the notion that PrPC plays at least two roles in prion diseases, by acting as a...
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