Article
Interactions outside the proteinase-binding loop contribute significantly to the inhibition of activated coagulation factor XII by its canonical inhibitor from corn.
The Journal of biological chemistry - 16 May 2014
Korneeva Vera A, Trubetskov Mikhail M, Korshunova Alena V, Lushchekina Sofya V, Kolyadko Vladimir N, Sergienko Olga V, Lunin Vladimir G, Panteleev Mikhail A, Ataullakhanov Fazoil I
Abstract excerpt
Activated factor XII (FXIIa) is selectively inhibited by corn Hageman factor inhibitor (CHFI) among other plasma proteases. CHFI is considered a canonical serine protease inhibitor that interacts with FXIIa through its protease-binding loop. Here we examined whether the protease-binding loop alone is sufficient for the selective inhibition of serine proteases or whether other regions of a canonical inhibitor are...
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