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Article

CpaA Is a Glycan-Specific Adamalysin-like Protease Secreted by Acinetobacter baumannii That Inactivates Coagulation Factor XII.

mBio - 18 Dec 2018

Waack Ursula, Warnock Mark, Yee Andrew, Huttinger Zachary, Smith Sara, Kumar Ayush, Deroux Alban, Ginsburg David, Mobley Harry L T, Lawrence Daniel A, Sandkvist Maria

Abstract excerpt

Antibiotic-resistant Acinetobacter baumannii is increasingly recognized as a cause of difficult-to-treat nosocomial infections, including pneumonia, wound infections, and bacteremia. Previous studies have demonstrated that the metalloprotease CpaA contributes to virulence and prolongs clotting time when added to human plasma as measured by the activated partial thromboplastin time (aPTT) assay. Here, we show that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30563903
DOI: 10.1128/mBio.01606-18
PMCID: PMC6299215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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