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Article

Contributions of basic amino acids in the autolysis loop of factor XIa to serpin specificity.

Biochemistry - 8 Aug 2006

Rezaie Alireza R, Sun Mao-fu, Gailani David

Abstract excerpt

The autolysis loops (amino acids 143-154, chymotrypsinogen numbering) of plasma serine proteases play key roles in determining the specificity of protease inhibition by plasma serpins. We studied the importance of four basic residues (Arg-144, Lys-145, Arg-147, and Lys-149) in the autolysis loop of the coagulation protease factor XIa (fXIa) for inhibition by serpins. Recombinant fXIa mutants, in which these...

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PMID: 16878977
DOI: 10.1021/bi060820+

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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