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Article

In vivo activation and functions of the protease factor XII

1 Jan 2014

Abstract excerpt

Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. The biochemistry of the contact system in vitro is well understood; however, its in vivo functions are just beginning to emerge. The current review concentrates on activators...

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PMID: 25187064
DOI: 10.1160/th14-04-0311

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