Article
Activated factor XI increases the procoagulant activity of the extrinsic pathway by inactivating tissue factor pathway inhibitor.
Blood - 26 Feb 2015
Puy Cristina, Tucker Erik I, Matafonov Anton, Cheng Qiufang, Zientek Keith D, Gailani Dave, Gruber András, McCarty Owen J T
Abstract excerpt
Activation of coagulation factor XI (FXI) may play a role in hemostasis. The primary substrate of activated FXI (FXIa) is FIX, leading to FX activation (FXa) and thrombin generation. However, recent studies suggest the hemostatic role of FXI may not be restricted to the activation of FIX. We explored whether FXI could interact with and inhibit the activity of tissue factor pathway inhibitor (TFPI). TFPI is an...
Topics
- Blood Coagulation
- Blood Platelets
- Blotting, Western
- Cells, Cultured
- Factor IX
- Factor XIa
- Factor Xa
- Fibrin
- Flow Cytometry
- Human Umbilical Vein Endothelial Cells
- Humans
- Lipoproteins
- Mutation
- Recombinant Proteins