Coagulation factor XII protease domain crystal structure.

doi:10.1111/jth.12849

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Article

Coagulation factor XII protease domain crystal structure.

Journal of thrombosis and haemostasis : JTH - 1 Apr 2015

Pathak M, Wilmann P, Awford J, Li C, Hamad B K, Fischer P M, Dreveny I, Dekker L V, Emsley J

Abstract excerpt

BACKGROUND: Coagulation factor XII is a serine protease that is important for kinin generation and blood coagulation, cleaving the substrates plasma kallikrein and FXI. OBJECTIVE: To investigate FXII zymogen activation and substrate recognition by determining the crystal structure of the FXII protease domain. METHODS AND RESULTS: A series of recombinant FXII protease constructs were characterized by measurement...

Topics

Blood Coagulation
Catalytic Domain
Crystallography, X-Ray
Enzyme Activation
Enzyme Precursors
Factor XII
Factor XIIa
Humans
Kallikreins
Kinetics
Models, Molecular
Mutation
Protein Binding
Protein Structure, Tertiary
Recombinant Proteins

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Identifiers

PMID: 25604127
DOI: 10.1111/jth.12849
PMCID: PMC4418343

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Structure-Activity Relationship

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