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Article

The role of β-barrels 1 and 2 in the enzymatic activity of factor XIII A-subunit.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2018

Hethershaw E L, Adamson P J, Smith K A, Goldsberry W N, Pease R J, Radford S E, Grant P J, Ariëns R A S, Maurer M C, Philippou H

Abstract excerpt

Essentials The roles of β-barrels 1 and 2 in factor XIII (FXIII) are currently unknown. FXIII truncations lacking β-barrel 2, both β-barrels, or full length FXIII, were made. Removing β-barrel 2 caused total loss of activity, removing both β-barrels returned 30% activity. β-barrel 2 is necessary for exposure of the active site cysteine during activation. SUMMARY: Background Factor XIII is composed of an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29675848
DOI: 10.1111/jth.14128
PMCID: PMC6175083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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